Statements (18)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:retinoblastoma |
| https://www.w3.org/2000/01/rdf-schema#label |
retinoblastoma pathway
|
| gptkbp:involves |
gptkb:cyclin_D
gptkb:pRB_protein gptkb:RB1_gene gptkb:CDK4 gptkb:CDK6 gptkb:E2F_transcription_factors CDK inhibitors |
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:mechanismOfAction |
pRB inhibits E2F
phosphorylation of pRB releases E2F |
| gptkbp:regulates |
gptkb:G1/S_transition
cell cycle |
| gptkbp:bfsParent |
gptkb:E2F1
|
| gptkbp:bfsLayer |
7
|