Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Biology
|
| gptkbp:associated_with |
gptkb:juvenile_idiopathic_arthritis
gptkb:neurodegenerative_diseases fibrosis cardiovascular diseases cancer progression pulmonary diseases diabetes complications chronic wounds skin aging |
| gptkbp:function |
degrade extracellular matrix components
|
| https://www.w3.org/2000/01/rdf-schema#label |
matrix metalloproteinases
|
| gptkbp:initiated_by |
proteolytic cleavage
tissue inhibitors of metalloproteinases |
| gptkbp:involved_in |
gptkb:disease
gptkb:cystic_fibrosis gptkb:multiple_sclerosis cell differentiation cell proliferation immune response autoimmune diseases inflammation muscle regeneration embryogenesis extracellular matrix remodeling periodontal disease angiogenesis atherosclerosis chronic inflammation tissue repair cell migration metastasis cellular signaling tissue remodeling bone remodeling gastrointestinal disorders oral diseases neovascularization cancer metastasis cancer therapy resistance tumor invasion tissue fibrosis neoplastic diseases liver fibrosis extracellular matrix turnover |
| gptkbp:is_regulated_by |
growth factors
cytokines |
| gptkbp:produced_by |
fibroblasts
|
| gptkbp:regulatory_compliance |
transcription factors
|
| gptkbp:role |
wound healing
|
| gptkbp:scientific_classification |
zinc-dependent endopeptidases
|
| gptkbp:type_of |
MMP-1
MMP-14 MMP-2 MMP-9 MMP-3 |
| gptkbp:bfsParent |
gptkb:A2_M
gptkb:IL-17_A |
| gptkbp:bfsLayer |
6
|