matrix metalloproteinases

URI: https://gptkb.org/entity/matrix_metalloproteinases

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:abbreviation	MMPs
gptkbp:activatedBy	activated by proteolytic cleavage secreted as inactive proenzymes
gptkbp:associatedWith	arthritis cardiovascular diseases cancer progression
gptkbp:clinical_use	biomarkers for disease
gptkbp:cofactor	zinc
gptkbp:discoveredBy	Charles Lapiere Jerome Gross
gptkbp:discoveredIn	1962
gptkbp:encodedBy	MMP genes
gptkbp:family	gptkb:MMP-13 gptkb:MMP-1 gptkb:MMP-2 gptkb:MMP-3 gptkb:MMP-7 gptkb:MMP-9 MMP-14 MMP-8
gptkbp:function	degrade extracellular matrix proteins regulate tissue remodeling
https://www.w3.org/2000/01/rdf-schema#label	matrix metalloproteinases
gptkbp:inhibitedBy	tissue inhibitors of metalloproteinases
gptkbp:locatedOnChromosome	gptkb:chromosome_14 gptkb:chromosome_16 chromosome 1 chromosome 11
gptkbp:location	extracellular space
gptkbp:potential_therapy_target	gptkb:cancer osteoarthritis fibrosis
gptkbp:regulates	regulated by hormones regulated by growth factors regulated by cytokines
gptkbp:role	embryonic development wound healing angiogenesis cell migration inflammation metastasis
gptkbp:structure	contain catalytic domain contain hemopexin-like domain
gptkbp:substrate	gptkb:fibronectin gptkb:elastin gptkb:laminin collagen gelatin
gptkbp:bfsParent	gptkb:c-Jun gptkb:Fas_ligand gptkb:Extracellular_Matrix gptkb:fibronectin gptkb:Extracellular_matrix gptkb:Type_III_collagen gptkb:CD44 gptkb:MMP1 gptkb:TIMP3 gptkb:Fas_ligand_(FasL)
gptkbp:bfsLayer	7