|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:collagenase_3
|
|
gptkbp:associatedWith
|
osteoarthritis
tumor invasion
|
|
gptkbp:cleavage
|
activated by proteolytic cleavage
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:EC_number
|
3.4.24.22
|
|
gptkbp:encodedBy
|
MMP13 gene
|
|
gptkbp:fullName
|
gptkb:matrix_metallopeptidase_13
|
|
gptkbp:function
|
degradation of extracellular matrix
collagenase activity
|
|
gptkbp:gene
|
gptkb:MMP13
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP-13
|
|
gptkbp:inhibitedBy
|
tissue inhibitor of metalloproteinases (TIMP)
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
54 kDa (proenzyme)
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
extracellular matrix organization
collagen degradation
|
|
gptkbp:regulates
|
induced by cytokines
regulated by transcription factors
|
|
gptkbp:structure
|
contains zinc-binding motif
|
|
gptkbp:substrate
|
gptkb:collagen_type_I
gptkb:collagen_type_II
gptkb:collagen_type_III
|
|
gptkbp:tissue_specificity
|
gptkb:bone
collagen
synovium
|
|
gptkbp:UniProtID
|
gptkb:P45452
|
|
gptkbp:bfsParent
|
gptkb:MMP13
gptkb:Matrix_metalloproteinase
|
|
gptkbp:bfsLayer
|
7
|