|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
activated by proteolytic cleavage
secreted as inactive proenzyme
|
|
gptkbp:alternativeName
|
gptkb:gelatinase_B
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
arthritis
chronic obstructive pulmonary disease
|
|
gptkbp:cofactor
|
zinc
calcium
|
|
gptkbp:discoveredBy
|
gptkb:Gail_R._Martin
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:EC_number
|
3.4.24.35
|
|
gptkbp:Entrez_Gene_ID
|
4318
ENSG00000100985
|
|
gptkbp:expressedIn
|
macrophages
fibroblasts
neutrophils
|
|
gptkbp:fullName
|
gptkb:matrix_metallopeptidase_9
|
|
gptkbp:function
|
involved in inflammation
degrades extracellular matrix proteins
involved in tissue remodeling
involved in cancer metastasis
|
|
gptkbp:gene
|
gptkb:MMP9
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:7156
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP-9
|
|
gptkbp:inhibitedBy
|
TIMP-1
TIMP-2
TIMP-3
TIMP-4
|
|
gptkbp:locatedIn
|
extracellular space
|
|
gptkbp:locatedOnChromosome
|
20q13.12
|
|
gptkbp:molecularWeight
|
92 kDa
|
|
gptkbp:OMIM
|
120361
|
|
gptkbp:PDB
|
1GKC
|
|
gptkbp:RefSeq
|
NM_004994
|
|
gptkbp:role
|
wound healing
angiogenesis
neuroinflammation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains catalytic domain
contains fibronectin type II-like repeats
contains hemopexin-like domain
|
|
gptkbp:substrate
|
gptkb:elastin
gptkb:aggrecan
gptkb:collagen_type_IV
gelatin
|
|
gptkbp:UniProtID
|
P14780
|
|
gptkbp:bfsParent
|
gptkb:c-Jun
gptkb:Matrix_metalloproteinase
|
|
gptkbp:bfsLayer
|
7
|