|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:alternativeName
|
gptkb:Apo-1_ligand
gptkb:TNFSF6
CD95 ligand
|
|
gptkbp:binds
|
Fas receptor (CD95)
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
extracellular region
|
|
gptkbp:cleavage
|
gptkb:matrix_metalloproteinases
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:FASLG_gene
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_(NK)_cells
activated T cells
immune privileged tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
induces apoptosis
regulates immune system
|
|
gptkbp:GO
|
gptkb:GO:0005125
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fas ligand (FasL)
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:caspase-8
gptkb:TRAIL
|
|
gptkbp:involvedIn
|
peripheral tolerance
activation-induced cell death (AICD)
immune homeostasis
|
|
gptkbp:length
|
281 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1q23
|
|
gptkbp:medicalUse
|
target for immunotherapy
|
|
gptkbp:memberOf
|
tumor necrosis factor (TNF) superfamily
|
|
gptkbp:molecularWeight
|
40 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome_(ALPS)
|
|
gptkbp:OMIM
|
134638
|
|
gptkbp:orthologIn
|
gptkb:lion
gptkb:mouse
right
|
|
gptkbp:pathway
|
immune response regulation
extrinsic apoptotic signaling pathway
|
|
gptkbp:PDB
|
4MSV
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:regulates
|
downregulated by anti-inflammatory cytokines
upregulated by T cell activation
|
|
gptkbp:role
|
gptkb:cancer
autoimmune disease
immune evasion
|
|
gptkbp:solubleForm
|
sFasL
|
|
gptkbp:structure
|
type-II transmembrane protein
|
|
gptkbp:UniProtID
|
gptkb:P48023
|
|
gptkbp:bfsParent
|
gptkb:Fas
|
|
gptkbp:bfsLayer
|
6
|