|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:collagenase-1
fibroblast collagenase
|
|
gptkbp:associatedWith
|
gptkb:cancer
osteoarthritis
rheumatoid arthritis
|
|
gptkbp:cofactor
|
zinc
calcium
|
|
gptkbp:component
|
extracellular region
|
|
gptkbp:discoveredBy
|
gptkb:G._Murphy
|
|
gptkbp:discoveredIn
|
1968
|
|
gptkbp:encodedBy
|
MMP1 gene
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.4.24.7
|
|
gptkbp:expressedIn
|
upregulated in cancer
upregulated in inflammation
|
|
gptkbp:family
|
gptkb:matrix_metalloproteinase
|
|
gptkbp:fullName
|
Matrix metalloproteinase-1
|
|
gptkbp:function
|
metalloendopeptidase activity
involved in arthritis
involved in tissue remodeling
involved in wound healing
degrades interstitial collagens
|
|
gptkbp:gene
|
gptkb:MMP1
|
|
gptkbp:GOProcess
|
extracellular matrix disassembly
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP-1
|
|
gptkbp:inhibitedBy
|
TIMP-1
TIMP-2
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q22.3
|
|
gptkbp:location
|
extracellular matrix
secreted
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Mmp1a
mouse Mmp1b
|
|
gptkbp:PDB
|
1CGL
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic activation
|
|
gptkbp:regulates
|
regulated by hormones
regulated by growth factors
regulated by cytokines
|
|
gptkbp:structure
|
contains a hemopexin-like domain
contains a catalytic domain
contains a propeptide domain
|
|
gptkbp:substrate
|
gptkb:collagen_type_I
gptkb:collagen_type_II
gptkb:collagen_type_III
|
|
gptkbp:UniProtID
|
P03956
|
|
gptkbp:bfsParent
|
gptkb:Matrix_metalloproteinase
|
|
gptkbp:bfsLayer
|
7
|