|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
activated by proteolytic cleavage
|
|
gptkbp:alternativeName
|
gptkb:matrilysin
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
gastric cancer
inflammatory bowel disease
|
|
gptkbp:calciumBinding
|
yes
|
|
gptkbp:cleavage
|
gptkb:E-cadherin
pro-TNF-alpha
pro-defensin
|
|
gptkbp:discoveredBy
|
gptkb:G._Murphy_et_al.
|
|
gptkbp:EC_number
|
3.4.24.23
|
|
gptkbp:encodedBy
|
gptkb:MMP7_gene
|
|
gptkbp:expressedIn
|
gastrointestinal tract
epithelial cells
tumor tissue
|
|
gptkbp:family
|
gptkb:matrix_metalloproteinase_family
|
|
gptkbp:form
|
secreted as inactive proenzyme
|
|
gptkbp:fullName
|
gptkb:matrix_metallopeptidase_7
|
|
gptkbp:function
|
degrades components of the extracellular matrix
involved in cancer progression
involved in tissue remodeling
involved in wound healing
|
|
gptkbp:gene
|
gptkb:MMP7
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:7176
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP-7
|
|
gptkbp:inhibitedBy
|
TIMP-1
TIMP-2
TIMP-3
TIMP-4
|
|
gptkbp:locatedOnChromosome
|
chromosome 11q22.2
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:OMIM
|
600908
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1MMQ
|
|
gptkbp:structure
|
lacks hemopexin domain
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:casein
gptkb:collagen_IV
gelatin
proteoglycans
|
|
gptkbp:UniProtID
|
gptkb:P09237
|
|
gptkbp:zincBinding
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Matrix_metalloproteinase
|
|
gptkbp:bfsLayer
|
7
|