|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
activated by proteolytic cleavage
secreted as inactive proenzyme
|
|
gptkbp:alternativeName
|
Stromelysin-1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
arthritis
|
|
gptkbp:EC_number
|
3.4.24.17
|
|
gptkbp:encodedBy
|
MMP3 gene
|
|
gptkbp:Enzyme_Commission
|
3.4.24.17
|
|
gptkbp:family
|
gptkb:matrix_metalloproteinase_family
|
|
gptkbp:fullName
|
Matrix metalloproteinase-3
|
|
gptkbp:function
|
degradation of extracellular matrix
activation of other MMPs
|
|
gptkbp:gene
|
gptkb:MMP3
|
|
gptkbp:HGNC_ID
|
7154
|
|
gptkbp:inhibitedBy
|
TIMP-1
TIMP-2
TIMP-3
TIMP-4
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q22.3
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:OMIM
|
185250
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1CQR
1G4K
1HY7
1SLN
2D1N
4G9L
4G9M
4G9N
4G9O
4G9P
|
|
gptkbp:structure
|
contains zinc-binding motif
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:collagen
gptkb:laminin
gelatin
proteoglycans
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:skin
gptkb:collagen
gptkb:skeletal_muscle
gptkb:placenta
uterus
breast tissue
synovial membrane
|
|
gptkbp:UniProtID
|
gptkb:P08254
|
|
gptkbp:bfsParent
|
gptkb:Matrix_metalloproteinase
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP-3
|