|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
activated by MT1-MMP
secreted as proenzyme
|
|
gptkbp:alternativeName
|
gptkb:gelatinase_A
|
|
gptkbp:associatedWith
|
Torg syndrome
multicentric osteolysis
|
|
gptkbp:cofactor
|
zinc
calcium
|
|
gptkbp:discoveredBy
|
gptkb:G._Murphy
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:EC_number
|
3.4.24.24
|
|
gptkbp:Entrez_Gene_ID
|
4313
ENSG00000087245
|
|
gptkbp:expressedIn
|
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:fullName
|
Matrix metallopeptidase 2
|
|
gptkbp:function
|
degrades type IV collagen
involved in extracellular matrix remodeling
|
|
gptkbp:gene
|
gptkb:MMP2
|
|
gptkbp:HGNC_ID
|
7173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP-2
|
|
gptkbp:inhibitedBy
|
TIMP-1
TIMP-2
|
|
gptkbp:locale
|
extracellular space
cell surface
|
|
gptkbp:locatedOnChromosome
|
gptkb:16q12.2
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:OMIM
|
120360
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Mmp2
rat Mmp2
|
|
gptkbp:pathway
|
angiogenesis
extracellular matrix organization
|
|
gptkbp:PDB
|
1CK7
|
|
gptkbp:proteinFamily
|
gptkb:matrix_metalloproteinases
|
|
gptkbp:RefSeq
|
NM_004530
|
|
gptkbp:significance
|
implicated in cardiovascular disease
implicated in cancer metastasis
|
|
gptkbp:structure
|
contains a hemopexin-like domain
contains a catalytic domain
contains three fibronectin type II domains
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:type_IV_collagen
gptkb:laminin
gelatin
|
|
gptkbp:UniProtID
|
P08253
|
|
gptkbp:bfsParent
|
gptkb:Matrix_metalloproteinase
|
|
gptkbp:bfsLayer
|
7
|