|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Sorsby_fundus_dystrophy
|
|
gptkbp:encodedBy
|
gptkb:TIMP3_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100234
|
|
gptkbp:expressedIn
|
widely expressed in tissues
|
|
gptkbp:fullName
|
gptkb:Tissue_inhibitor_of_metalloproteinases_3
|
|
gptkbp:function
|
inhibits angiogenesis
inhibits matrix metalloproteinases
regulates extracellular matrix composition
|
|
gptkbp:gene
|
gptkb:TIMP3
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11821
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIMP3
|
|
gptkbp:inhibitedBy
|
gptkb:ADAM17
gptkb:MMP2
gptkb:MMP9
|
|
gptkbp:length
|
211 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 22
|
|
gptkbp:location
|
extracellular matrix
|
|
gptkbp:molecularWeight
|
24 kDa
|
|
gptkbp:mutationAssociatedWith
|
mutations cause Sorsby fundus dystrophy
|
|
gptkbp:OMIM
|
188826
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1UEA
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:RefSeq
|
gptkb:NM_000362
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
angiogenesis
|
|
gptkbp:relatedTo
|
gptkb:cancer
gptkb:matrix_metalloproteinases
inflammation
extracellular matrix remodeling
|
|
gptkbp:structure
|
contains N-terminal and C-terminal domains
|
|
gptkbp:UniProtID
|
gptkb:P35625
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|