|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ERBB
gptkb:ERBB1
gptkb:HER1
mENA
|
|
gptkbp:associatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
|
|
gptkbp:biologicalProcess
|
signal transduction
cell growth
ATP binding
apoptosis regulation
protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_Cohen
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146648
1956
|
|
gptkbp:fullName
|
gptkb:epidermal_growth_factor_receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
cell differentiation regulation
cell proliferation regulation
|
|
gptkbp:gene
|
gptkb:EGFR
|
|
gptkbp:HGNC_ID
|
3236
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hsa:1956
|
|
gptkbp:length
|
1210 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
7
|
|
gptkbp:mutationAssociatedWith
|
gptkb:L858R
gptkb:T790M
exon 19 deletion
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Egfr
gptkb:rat_Egfr
|
|
gptkbp:pathway
|
gptkb:EGFR_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
1M17
2GS6
|
|
gptkbp:phosphorylates
|
Y1068
Y1173
|
|
gptkbp:product
|
gptkb:epidermal_growth_factor_receptor_protein
|
|
gptkbp:RefSeq
|
NM_005228
|
|
gptkbp:target
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
|
|
gptkbp:UniProtID
|
gptkb:P00533
|
|
gptkbp:bfsParent
|
gptkb:P15056
gptkb:P42338
|
|
gptkbp:bfsLayer
|
6
|