|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:abbreviation
|
gptkb:JNK
|
|
gptkbp:activatedBy
|
cytokines
UV radiation
heat shock
osmotic shock
reactive oxygen species
|
|
gptkbp:alternativeName
|
gptkb:JNK1
gptkb:JNK2
gptkb:JNK3
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:EC_number
|
2.7.11.24
|
|
gptkbp:encodedBy
|
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAPK8
|
|
gptkbp:function
|
regulation of gene expression
apoptosis regulation
cellular stress response
phosphorylation of c-Jun
inflammation regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Jun N-terminal kinases
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 10 (MAPK8)
chromosome 4 (MAPK10)
chromosome 5 (MAPK9)
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:phosphorylates
|
gptkb:Bcl-2
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
gptkb:p53
gptkb:Bim
gptkb:c-Fos
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
transcription factors
|
|
gptkbp:relatedTo
|
gptkb:MAPK_pathway
gptkb:cancer
gptkb:diabetes
inflammatory diseases
neurodegeneration
cell death
stress-activated protein kinases
|
|
gptkbp:subclassOf
|
gptkb:mitogen-activated_protein_kinase
|
|
gptkbp:UniProtID
|
gptkb:P45983
gptkb:P53779
P45984
|
|
gptkbp:bfsParent
|
gptkb:JNK_proteins
gptkb:c-Jun_N-terminal_kinase_pathway
gptkb:JNK1
gptkb:JNK2
|
|
gptkbp:bfsLayer
|
7
|