|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:MAPK_pathway
gptkb:NF-κB_pathway
caspase cascade
|
|
gptkbp:associatedWith
|
gptkb:cancer
sepsis
autoimmune diseases
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNF signaling pathway
|
|
gptkbp:involves
|
gptkb:TAK1
gptkb:FADD
gptkb:BID
gptkb:BAX
gptkb:JAK/STAT_pathway
gptkb:JNK
gptkb:A20
gptkb:ROS
gptkb:BCL2
gptkb:Caspase-3
gptkb:TRADD
gptkb:CYLD
gptkb:IKK_complex
gptkb:TRAF2
gptkb:Caspase-8
gptkb:FLIP
gptkb:NEMO
gptkb:RIPK1
gptkb:XIAP
gptkb:cIAP1
gptkb:cIAP2
ASK1
ceramide
SMAC/DIABLO
Sphingomyelinase
TNF receptor 1 (TNFR1)
TNF receptor 2 (TNFR2)
tumor necrosis factor (TNF)
|
|
gptkbp:KEGGID
|
hsa04668
|
|
gptkbp:regulates
|
apoptosis
cell survival
inflammation
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:certolizumab_pegol
gptkb:adalimumab
|
|
gptkbp:bfsParent
|
gptkb:FADD
gptkb:TNFAIP3
gptkb:Receptor-interacting_protein_kinase_(RIPK)_family
gptkb:TNF_gene
|
|
gptkbp:bfsLayer
|
7
|