|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:FADD
death receptors
|
|
gptkbp:alias
|
gptkb:FLICE
gptkb:MACH
gptkb:Mch5
gptkb:CAP4
apoptotic cysteine protease
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
apoptosis
inflammation
immune response
|
|
gptkbp:catalyzes
|
cleavage of aspartic acid peptide bonds
|
|
gptkbp:cleavage
|
gptkb:Bid
procaspase-3
procaspase-7
p10 subunit
p18 subunit
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:EC_number
|
3.4.22.61
|
|
gptkbp:encodedBy
|
gptkb:CASP8_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:CASP8
|
|
gptkbp:function
|
initiator caspase in apoptosis
mediates extrinsic apoptotic pathway
|
|
gptkbp:gene
|
gptkb:CASP8
|
|
gptkbp:HGNC_ID
|
1509
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Caspase-8
|
|
gptkbp:inhibitedBy
|
gptkb:c-FLIP
viral proteins
|
|
gptkbp:involvedIn
|
developmental processes
cell death
immune cell homeostasis
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
2q33-q34
|
|
gptkbp:molecularWeight
|
55 kDa (precursor)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
immunodeficiency
|
|
gptkbp:OMIM
|
601763
|
|
gptkbp:orthologIn
|
gptkb:meat
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:partOf
|
gptkb:death-inducing_signaling_complex_(DISC)
|
|
gptkbp:PDB
|
gptkb:1QTN
|
|
gptkbp:RefSeq
|
NP_001220.2
|
|
gptkbp:UniProtID
|
gptkb:Q14790
|
|
gptkbp:bfsParent
|
gptkb:FADD
gptkb:Caspase
|
|
gptkbp:bfsLayer
|
7
|