Statements (73)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
7
|
| gptkbp:bfsParent |
gptkb:Iκ_B_proteins
|
| gptkbp:community |
gene expression
|
| gptkbp:consists_of |
IK Kα
IK Kβ IK Kγ |
| gptkbp:established |
anti-inflammatory agents
NF-κ B transcription factors pro-inflammatory cytokines |
| gptkbp:has_role |
immune response
cell survival |
| https://www.w3.org/2000/01/rdf-schema#label |
IKK complex
|
| gptkbp:interacts_with |
gptkb:Iκ_B_proteins
|
| gptkbp:is_aimed_at |
drug development
therapeutic drugs |
| gptkbp:is_associated_with |
gptkb:psychologist
chronic diseases chronic kidney disease chronic inflammation aging process metastasis chronic obstructive pulmonary disease chronic liver disease |
| gptkbp:is_critical_for |
T cell activation
immune tolerance immune system development B cell function host defense mechanisms innate immune activation |
| gptkbp:is_essential_for |
tumorigenesis
|
| gptkbp:is_involved_in |
apoptosis regulation
cell cycle regulation cell differentiation cellular homeostasis metabolic disorders wound healing neuroinflammation cellular proliferation cellular senescence tumor microenvironment angiogenesis tissue repair viral infections neuroprotection cell migration cellular signaling pathways cytokine production cellular repair mechanisms cellular stress responses tissue inflammation cellular detoxification neoplastic transformation cellular apoptosis cellular stress adaptation NF-κ B signaling pathway |
| gptkbp:is_linked_to |
gptkb:computer
autoimmune diseases chronic pain metabolic syndrome fibrosis cardiovascular diseases cancer progression allergic responses |
| gptkbp:is_part_of |
signal transduction pathways
innate immune response |
| gptkbp:is_represented_in |
various tissues
|
| gptkbp:is_studied_in |
therapeutic interventions
cancer research |
| gptkbp:located_in |
cytoplasm
|
| gptkbp:regulates |
transcription factors
inflammatory responses micro RN As |