Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:IL-1
gptkb:virus gptkb:TNF-α gptkb:LPS pro-inflammatory cytokines pattern recognition receptors |
| gptkbp:alsoKnownAs |
IκB kinase complex
|
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases chronic inflammation |
| gptkbp:composedOf |
IKKα
IKKβ IKKγ |
| gptkbp:discoveredIn |
late 1990s
|
| gptkbp:function |
activates NF-κB pathway
phosphorylates IκB proteins |
| gptkbp:geneEncodingComponent |
gptkb:CHUK
IKBKB IKBKG |
| gptkbp:inhibitedBy |
BMS-345541
TPCA-1 |
| gptkbp:involvedIn |
canonical NF-κB signaling pathway
non-canonical NF-κB signaling pathway |
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:molecularWeight |
~700 kDa
|
| gptkbp:mutationInIKKγ |
causes immunodeficiency
causes incontinentia pigmenti |
| gptkbp:phosphorylates |
gptkb:IκBα
IκBβ IκBε Ser32 of IκBα Ser36 of IκBα |
| gptkbp:recruitedFrom |
gptkb:TRAF_proteins
|
| gptkbp:regulates |
gptkb:immune_response
inflammatory response |
| gptkbp:requires |
NF-κB activation
IκB degradation NF-κB nuclear translocation |
| gptkbp:structure |
heterotrimeric
|
| gptkbp:studiedIn |
cell signaling research
|
| gptkbp:subunit |
catalytic subunit
regulatory subunit |
| gptkbp:subunitIKKα |
catalytic
|
| gptkbp:subunitIKKβ |
catalytic
|
| gptkbp:subunitIKKγ |
regulatory
|
| gptkbp:target |
therapeutic drugs
|
| gptkbp:bfsParent |
gptkb:TAK1
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
IKK complex
|