|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:IL-1
gptkb:virus
gptkb:TNF-α
gptkb:LPS
pro-inflammatory cytokines
pattern recognition receptors
|
|
gptkbp:alsoKnownAs
|
IκB kinase complex
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
chronic inflammation
|
|
gptkbp:composedOf
|
IKKα
IKKβ
IKKγ
|
|
gptkbp:discoveredIn
|
late 1990s
|
|
gptkbp:function
|
activates NF-κB pathway
phosphorylates IκB proteins
|
|
gptkbp:geneEncodingComponent
|
gptkb:CHUK
IKBKB
IKBKG
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IKK complex
|
|
gptkbp:inhibitedBy
|
BMS-345541
TPCA-1
|
|
gptkbp:involvedIn
|
canonical NF-κB signaling pathway
non-canonical NF-κB signaling pathway
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~700 kDa
|
|
gptkbp:mutationInIKKγ
|
causes immunodeficiency
causes incontinentia pigmenti
|
|
gptkbp:phosphorylates
|
gptkb:IκBα
IκBβ
IκBε
Ser32 of IκBα
Ser36 of IκBα
|
|
gptkbp:recruitedFrom
|
gptkb:TRAF_proteins
|
|
gptkbp:regulates
|
immune response
inflammatory response
|
|
gptkbp:requires
|
NF-κB activation
IκB degradation
NF-κB nuclear translocation
|
|
gptkbp:structure
|
heterotrimeric
|
|
gptkbp:studiedIn
|
cell signaling research
|
|
gptkbp:subunit
|
catalytic subunit
regulatory subunit
|
|
gptkbp:subunitIKKα
|
catalytic
|
|
gptkbp:subunitIKKβ
|
catalytic
|
|
gptkbp:subunitIKKγ
|
regulatory
|
|
gptkbp:target
|
therapeutic drugs
|
|
gptkbp:bfsParent
|
gptkb:TAK1
gptkb:NF-κB_pathway
gptkb:TNFAIP3
gptkb:vFLIP
gptkb:NF-kappaB_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|