|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:caspase-8
gptkb:caspase-9
|
|
gptkbp:alternativeName
|
gptkb:Yama
gptkb:CPP32
apopain
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
apoptotic process
cysteine-type endopeptidase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
cytosol
|
|
gptkbp:cleavage
|
gptkb:ICAD
poly(ADP-ribose) polymerase (PARP)
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:EC_number
|
3.4.22.56
|
|
gptkbp:encodedBy
|
CASP3 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000164305
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:family
|
gptkb:caspase_family
|
|
gptkbp:function
|
execution-phase apoptosis
|
|
gptkbp:gene
|
gptkb:CASP3
|
|
gptkbp:GOID
|
GO:0004197
|
|
gptkbp:HGNC_ID
|
HGNC:1504
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Caspase-3
|
|
gptkbp:inhibitedBy
|
gptkb:XIAP
BIRC proteins
z-DEVD-fmk
|
|
gptkbp:locatedOnChromosome
|
4q34
|
|
gptkbp:molecularWeight
|
12 kDa (small subunit, active)
17 kDa (large subunit, active)
32 kDa (inactive precursor)
|
|
gptkbp:OMIM
|
600636
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Casp3
|
|
gptkbp:pathway
|
intrinsic apoptosis pathway
extrinsic apoptosis pathway
|
|
gptkbp:PDB
|
gptkb:1PAU
|
|
gptkbp:postTranslationalModification
|
cleavage for activation
|
|
gptkbp:RefSeq
|
NP_004337.2
|
|
gptkbp:requires
|
DNA fragmentation during apoptosis
cellular morphological changes in apoptosis
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:subfamily
|
cysteine-aspartic proteases
|
|
gptkbp:substrate
|
Asp-Glu-Val-Asp (DEVD) sequence
|
|
gptkbp:UniProtID
|
P42574
|
|
gptkbp:bfsParent
|
gptkb:P49918
gptkb:Caspase
|
|
gptkbp:bfsLayer
|
7
|