Statements (79)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:GPCRs
|
| gptkbp:activatedBy |
gptkb:G_proteins
|
| gptkbp:alsoKnownAs |
seven-transmembrane receptors
|
| gptkbp:binds |
ligands
|
| gptkbp:database |
gptkb:GPCRdb
gptkb:NCBI_Gene gptkb:PDB gptkb:UniProt gptkb:IUPHAR/BPS_Guide_to_Pharmacology |
| gptkbp:discoveredBy |
gptkb:Robert_J._Lefkowitz
gptkb:Brian_Kobilka |
| gptkbp:example |
gptkb:receptor_tyrosine_kinase
gptkb:adenosine_receptor gptkb:angiotensin_receptor gptkb:beta-adrenergic_receptor gptkb:glucagon_receptor gptkb:muscarinic_acetylcholine_receptor gptkb:olfactory_receptor gptkb:rhodopsin cannabinoid receptor dopamine receptor opioid antihistamine bombesin receptor bradykinin receptor calcitonin receptor chemokine receptor cholecystokinin receptor endothelin receptor follicle-stimulating hormone receptor free fatty acid receptor frizzled receptor galanin receptor gonadotropin-releasing hormone receptor luteinizing hormone receptor melatonin receptor metabotropic glutamate receptor neuropeptide Y receptor neurotensin receptor orphan GPCR parathyroid hormone receptor prostaglandin receptor purinergic receptor somatostatin receptor tachykinin receptor thyrotropin-releasing hormone receptor trace amine-associated receptor vasoactive intestinal peptide receptor vasopressin receptor |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
signal transduction
|
| gptkbp:GO_term |
GO:0004930
|
| gptkbp:hasWikipediaPage |
https://en.wikipedia.org/wiki/G_protein-coupled_receptor
|
| https://www.w3.org/2000/01/rdf-schema#label |
G protein-coupled receptors
|
| gptkbp:involvedIn |
gptkb:DVD
cell growth immune response taste smell neurotransmission regulation of blood pressure regulation of mood |
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:MeSH_ID |
D018253
|
| gptkbp:NobelPrizeYear |
2012
Chemistry |
| gptkbp:OMIM |
601869
|
| gptkbp:percentageOfDrugsTargeting |
~34%
|
| gptkbp:structure |
extracellular N-terminus
intracellular C-terminus seven alpha-helical transmembrane domains |
| gptkbp:superfamily |
metabotropic glutamate receptors
rhodopsin-like receptors secretin receptor family |
| gptkbp:target |
pharmaceutical drugs
|
| gptkbp:transmembraneDomains |
7
|
| gptkbp:bfsParent |
gptkb:protein
|
| gptkbp:bfsLayer |
4
|