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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alias
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gptkb:BZS
gptkb:MHAM
gptkb:MMAC1
gptkb:PTEN1
gptkb:TEP1
gptkb:CWS1
gptkb:CWS10
gptkb:CWS11
gptkb:CWS12
gptkb:CWS13
gptkb:CWS14
gptkb:CWS15
gptkb:CWS16
gptkb:CWS17
gptkb:CWS18
gptkb:CWS19
gptkb:CWS2
gptkb:CWS20
gptkb:CWS21
gptkb:CWS22
gptkb:CWS23
gptkb:CWS24
gptkb:CWS25
gptkb:CWS26
gptkb:CWS27
gptkb:CWS28
gptkb:CWS29
gptkb:CWS3
gptkb:CWS30
gptkb:CWS31
gptkb:CWS32
gptkb:CWS33
gptkb:CWS34
gptkb:CWS35
gptkb:CWS36
gptkb:CWS37
gptkb:CWS38
gptkb:CWS39
gptkb:CWS4
gptkb:CWS40
gptkb:CWS41
gptkb:CWS42
gptkb:CWS43
gptkb:CWS44
gptkb:CWS45
gptkb:CWS46
gptkb:CWS47
gptkb:CWS48
gptkb:CWS49
gptkb:CWS5
gptkb:CWS50
gptkb:CWS6
gptkb:CWS7
gptkb:CWS8
gptkb:CWS9
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|
gptkbp:biologicalProcess
|
dephosphorylates phosphoinositide substrates
negatively regulates cell growth
negatively regulates cell migration
negatively regulates cell proliferation
negatively regulates cell survival
|
|
gptkbp:discoveredBy
|
gptkb:Peter_C._Steck
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gptkbp:discoveredIn
|
1997
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gptkbp:encodes
|
gptkb:PTEN_protein
|
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gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171862
5728
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gptkbp:expressedIn
|
many tissues
|
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gptkbp:fullName
|
gptkb:phosphatase_and_tensin_homolog
|
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gptkbp:function
|
tumor suppressor
phosphatase activity
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gptkbp:HGNC_ID
|
9588
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTEN gene
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q23.3
gptkb:chromosome_10
|
|
gptkbp:lossOfFunctionLeadsTo
|
tumorigenesis
uncontrolled cell growth
|
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gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease
gptkb:endometrial_cancer
gptkb:glioblastoma
prostate cancer
|
|
gptkbp:OMIM
|
601728
|
|
gptkbp:orthologInMouse
|
Pten
|
|
gptkbp:orthologInZebrafish
|
ptena
ptenb
|
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gptkbp:proteinFamily
|
C2 domain
PDZ-binding motif
phosphatase domain
|
|
gptkbp:regulates
|
gptkb:PI3K/AKT_signaling_pathway
apoptosis
angiogenesis
cell migration
cell cycle
|
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gptkbp:UniProtID
|
gptkb:P60484
|
|
gptkbp:bfsParent
|
gptkb:Bannayan–Riley–Ruvalcaba_syndrome
gptkb:PTEN_(phosphatase_and_tensin_homolog)
gptkb:Cowden_syndrome
gptkb:NM_000314
gptkb:phosphatase_and_tensin_homolog
|
|
gptkbp:bfsLayer
|
6
|