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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alias
|
gptkb:PI3KCA
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
gptkb:p110_alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
gptkb:glioblastoma
colorectal cancer
|
|
gptkbp:discoveredBy
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gptkb:Yutaka_Hara
|
|
gptkbp:encodes
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000121879
5290
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1994
|
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gptkbp:function
|
gptkb:catalytic_subunit_of_PI3K_alpha
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
8975
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CA gene
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:length
|
20 exons
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3q26.32
|
|
gptkbp:mutationAssociatedWith
|
germline mutation
somatic mutation
E542K
E545K
H1047R
increased cell proliferation
constitutive activation of PI3K
resistance to some cancer therapies
|
|
gptkbp:OMIM
|
171834
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3ca
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway
|
|
gptkbp:product
|
gptkb:p110α
|
|
gptkbp:proteinFamily
|
gptkb:phosphoinositide_3-kinase_family
|
|
gptkbp:regulates
|
cell proliferation
cell survival
cell growth
cell metabolism
cell motility
|
|
gptkbp:significance
|
tumor suppressor
cancer driver gene
|
|
gptkbp:target
|
gptkb:alpelisib
gptkb:copanlisib
gptkb:idelalisib
|
|
gptkbp:UniProtID
|
gptkb:P42336
|
|
gptkbp:bfsParent
|
gptkb:catalytic_subunit_of_PI3K_alpha
gptkb:p110-alpha
gptkb:phosphoinositide_3-kinase_complex
gptkb:PI3K-alpha
gptkb:PI3K_alpha
|
|
gptkbp:bfsLayer
|
6
|