|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PDGF-AA
gptkb:PDGF-AB
gptkb:PDGF-BB
|
|
gptkbp:alternativeName
|
gptkb:CD140a
gptkb:platelet-derived_growth_factor_receptor_alpha
gptkb:PDGFRα
|
|
gptkbp:binds
|
gptkb:platelet-derived_growth_factor_(PDGF)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:PDGFRA_gene
|
|
gptkbp:Entrez_Gene_ID
|
5156
ENSG00000134853
|
|
gptkbp:expressedIn
|
fibroblasts
mesenchymal cells
smooth muscle cells
|
|
gptkbp:formsHeterodimerWith
|
gptkb:PDGF_receptor_beta
|
|
gptkbp:function
|
cell differentiation
cell proliferation
cell migration
|
|
gptkbp:hasGlycosylation
|
yes
|
|
gptkbp:hasPhosphorylation
|
yes
|
|
gptkbp:HGNC_ID
|
HGNC:8803
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGF receptor alpha
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
cellular response to growth factor stimulus
|
|
gptkbp:ligand
|
gptkb:PDGF-A
gptkb:PDGF-B
gptkb:PDGF-C
gptkb:PDGF-D
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
4q12
|
|
gptkbp:molecularWeight
|
~170 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:glioblastoma
hypereosinophilic syndrome
gastrointestinal stromal tumor (GIST)
|
|
gptkbp:OMIM
|
173490
|
|
gptkbp:orthologInMouse
|
gptkb:Pdgfra
|
|
gptkbp:phosphorylates
|
downstream signaling proteins
|
|
gptkbp:RefSeq
|
NM_006206
|
|
gptkbp:target
|
gptkb:imatinib
gptkb:sunitinib
gptkb:crenolanib
|
|
gptkbp:UniProtID
|
P16234
|
|
gptkbp:bfsParent
|
gptkb:Platelet-derived_growth_factor
|
|
gptkbp:bfsLayer
|
6
|