|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PDGF-AB
gptkb:PDGF-BB
|
|
gptkbp:alternativeName
|
gptkb:PDGFRB
gptkb:beta-type_platelet-derived_growth_factor_receptor
gptkb:CD140b
|
|
gptkbp:associatedWith
|
gptkb:cancer
atherosclerosis
fibrosis
|
|
gptkbp:binds
|
gptkb:platelet-derived_growth_factor_(PDGF)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:EC_number
|
2.7.10.1
|
|
gptkbp:encodedBy
|
gptkb:PDGFRB_gene
|
|
gptkbp:expressedIn
|
fibroblasts
pericytes
smooth muscle cells
|
|
gptkbp:formsHeterodimerWith
|
gptkb:PDGF_receptor_alpha
|
|
gptkbp:function
|
cell differentiation
cell proliferation
angiogenesis
cell migration
|
|
gptkbp:HGNC_ID
|
8804
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
5q32
|
|
gptkbp:molecularWeight
|
~180 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:idiopathic_basal_ganglia_calcification
gptkb:infantile_myofibromatosis
myeloproliferative neoplasms
|
|
gptkbp:orthologInMouse
|
gptkb:Pdgfrb
|
|
gptkbp:PDB
|
3MJG
5GRN
|
|
gptkbp:phosphorylates
|
downstream signaling proteins
|
|
gptkbp:target
|
gptkb:sorafenib
gptkb:imatinib
gptkb:sunitinib
|
|
gptkbp:UniProtID
|
gptkb:P09619
|
|
gptkbp:bfsParent
|
gptkb:PDGF
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGF receptor beta
|