|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
atherosclerosis
fibrosis
|
|
gptkbp:component
|
extracellular space
|
|
gptkbp:discoveredBy
|
R. Ross et al.
|
|
gptkbp:form
|
homodimer
heterodimer with PDGF-BB
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
Platelet-derived growth factor subunit A
|
|
gptkbp:function
|
growth factor activity
mitogenic factor for cells of mesenchymal origin
|
|
gptkbp:gene
|
gptkb:PDGFA
|
|
gptkbp:GOProcess
|
positive regulation of cell proliferation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGF-AA
|
|
gptkbp:involvedIn
|
cell proliferation
angiogenesis
cell migration
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p22
|
|
gptkbp:molecularWeight
|
14-17 kDa (monomer)
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
3MJK
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:recipient
|
gptkb:PDGF_receptor_alpha
gptkb:PDGF_receptor_beta
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
|
|
gptkbp:secretes
|
yes
|
|
gptkbp:structure
|
disulfide-linked dimer
|
|
gptkbp:UniProtID
|
P04085
|
|
gptkbp:bfsParent
|
gptkb:PDGFR-beta
gptkb:PDGF_receptor_alpha
|
|
gptkbp:bfsLayer
|
7
|