|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD140a
gptkb:PDGFR-2
gptkb:PDGFR-alpha
|
|
gptkbp:associatedWith
|
gptkb:gastrointestinal_stromal_tumor
gptkb:glioblastoma
hypereosinophilic syndrome
|
|
gptkbp:clinicalTrialPhase
|
gptkb:FoundationOne_CDx
Oncomine Focus Assay
|
|
gptkbp:discoveredBy
|
Stuart A. Aaronson
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodes
|
gptkb:PDGFRA_protein
|
|
gptkbp:Entrez_Gene_ID
|
5156
ENSG00000134853
|
|
gptkbp:expressedIn
|
fibroblasts
mesenchymal cells
smooth muscle cells
|
|
gptkbp:fullName
|
platelet derived growth factor receptor alpha
|
|
gptkbp:function
|
cell differentiation regulation
cell proliferation regulation
receptor tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:8803
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRA gene
|
|
gptkbp:length
|
1089 amino acids
|
|
gptkbp:locatedOnChromosome
|
4
4q12
|
|
gptkbp:molecularWeight
|
122 kDa
|
|
gptkbp:mutationAssociatedWith
|
deletion
gain of function
missense mutation
duplication
|
|
gptkbp:OMIM
|
173490
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:relatedTo
|
gptkb:PDGFRB_gene
PDGFA gene
PDGFB gene
|
|
gptkbp:subcellularLocation
|
gptkb:endosome
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:avapritinib
gptkb:imatinib
gptkb:crenolanib
|
|
gptkbp:UniProtID
|
P16234
|
|
gptkbp:bfsParent
|
gptkb:PDGFRα
|
|
gptkbp:bfsLayer
|
6
|