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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:Platelet-derived_growth_factor
|
|
gptkbp:binds
|
gptkb:PDGF_receptor_alpha
gptkb:PDGF_receptor_beta
|
|
gptkbp:category
|
growth factor
cytokine
|
|
gptkbp:composedOf
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A chain
B chain
C chain
D chain
|
|
gptkbp:discoveredBy
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gptkb:Russell_Ross
gptkb:Ulla_Westermark
|
|
gptkbp:discoveredIn
|
1974
|
|
gptkbp:form
|
heterodimers
homodimers
|
|
gptkbp:fullName
|
gptkb:Platelet-derived_growth_factor
|
|
gptkbp:function
|
wound healing
cell division
cell growth regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGF
|
|
gptkbp:locatedOnChromosome
|
chromosome 11 (PDGFD)
chromosome 22 (PDGFB)
chromosome 4 (PDGFC)
chromosome 7 (PDGFA)
|
|
gptkbp:producedBy
|
macrophages
platelets
endothelial cells
smooth muscle cells
|
|
gptkbp:recipient
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:relatedTo
|
atherosclerosis
angiogenesis
oncogenesis
fibrosis
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:cardiovascular_disease
fibrotic diseases
|
|
gptkbp:UniProtID
|
P01127 (PDGFB)
P04085 (PDGFA)
Q9GZP0 (PDGFD)
Q9NRA1 (PDGFC)
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:Platelet-derived_growth_factor
|
|
gptkbp:bfsLayer
|
6
|