|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:component
|
extracellular space
|
|
gptkbp:discoveredBy
|
gptkb:Russell_Ross
|
|
gptkbp:discoveredIn
|
1974
|
|
gptkbp:domain
|
PDGF/VEGF domain
|
|
gptkbp:encodedBy
|
PDGFA gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000197461
5154
|
|
gptkbp:form
|
homodimer
heterodimer with PDGF-B
|
|
gptkbp:fullName
|
Platelet-derived growth factor subunit A
|
|
gptkbp:function
|
growth factor activity
mitogenic factor for cells of mesenchymal origin
|
|
gptkbp:gene
|
gptkb:PDGFA
|
|
gptkbp:GOProcess
|
cell proliferation
angiogenesis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGF-A
|
|
gptkbp:length
|
211 amino acids (canonical isoform)
|
|
gptkbp:location
|
chromosome 7p22
|
|
gptkbp:molecularWeight
|
~15 kDa (monomer)
|
|
gptkbp:OMIM
|
190040
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
gptkb:Focal_adhesion_pathway
|
|
gptkbp:PDB
|
3MJK
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:recipient
|
gptkb:PDGF_receptor_alpha
gptkb:PDGF_receptor_beta
|
|
gptkbp:relatedTo
|
cell proliferation
embryonic development
wound healing
angiogenesis
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:secretes
|
macrophages
platelets
endothelial cells
smooth muscle cells
|
|
gptkbp:significance
|
implicated in cancer
implicated in atherosclerosis
implicated in fibrotic diseases
|
|
gptkbp:structure
|
contains a growth factor domain
|
|
gptkbp:UniProtID
|
P04085
|
|
gptkbp:bfsParent
|
gptkb:PDGFRα
|
|
gptkbp:bfsLayer
|
6
|