|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
atherosclerosis
fibrosis
|
|
gptkbp:component
|
extracellular space
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
PDGFB gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000100311
|
|
gptkbp:form
|
PDGF-AB dimer
PDGF-BB dimer
|
|
gptkbp:formsComplexWith
|
gptkb:PDGF-A
gptkb:PDGF-B
|
|
gptkbp:fullName
|
Platelet-derived growth factor subunit B
|
|
gptkbp:function
|
growth factor
growth factor activity
mitogen
|
|
gptkbp:gene
|
gptkb:PDGFB
|
|
gptkbp:GOProcess
|
positive regulation of cell proliferation
positive regulation of cell migration
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGF-B
|
|
gptkbp:involvedIn
|
cell proliferation
wound healing
angiogenesis
|
|
gptkbp:length
|
241 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q13.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:infantile_myofibromatosis
primary familial brain calcification
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2VRA
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:recipient
|
gptkb:PDGFR-beta
gptkb:PDGFR-alpha
|
|
gptkbp:RefSeq
|
NP_002600
|
|
gptkbp:secretes
|
yes
|
|
gptkbp:structure
|
contains growth factor domain
|
|
gptkbp:target
|
gptkb:dasatinib
gptkb:ponatinib
gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
gptkb:axitinib
gptkb:nintedanib
|
|
gptkbp:UniProtID
|
P01127
|
|
gptkbp:bfsParent
|
gptkb:PDGFRα
|
|
gptkbp:bfsLayer
|
6
|