Platelet-derived growth factor receptor alpha

URI: https://gptkb.org/entity/Platelet-derived_growth_factor_receptor_alpha
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:glioblastoma
hypereosinophilic syndrome
gastrointestinal stromal tumor (GIST)
gptkbp:biologicalProcess protein kinase activity
receptor activity
gptkbp:discoveredBy Andersson et al.
gptkbp:discoveredIn 1980s
gptkbp:Entrez_Gene_ID 5156
ENSG00000134853
gptkbp:expressedIn fibroblasts
mesenchymal cells
smooth muscle cells
gptkbp:forms_dimer_with gptkb:PDGFRB
itself (homodimer)
gptkbp:function cell differentiation
cell proliferation
embryonic development
wound healing
gptkbp:gene gptkb:PDGFRA
gptkbp:HGNC_ID HGNC:8803
https://www.w3.org/2000/01/rdf-schema#label Platelet-derived growth factor receptor alpha
gptkbp:ligand gptkb:platelet-derived_growth_factor_(PDGF)
gptkbp:locatedOnChromosome gptkb:chromosome_4
4q12
gptkbp:location gptkb:plasma_membrane
gptkbp:mutationAssociatedWith gain-of-function
loss-of-function
oncogenic transformation
gptkbp:OMIM 173490
gptkbp:orthologInMouse gptkb:Pdgfra
gptkbp:pathway gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
gptkbp:phosphorylates tyrosine residues
gptkbp:significance therapeutic target
biomarker for GIST
gptkbp:structure transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:targetOfDrug gptkb:imatinib
gptkb:sunitinib
gptkb:crenolanib
gptkbp:UniProtID P16234
gptkbp:bfsParent gptkb:PDGFRα
gptkbp:bfsLayer 6