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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:TrkA
gptkb:Neurotrophic_tyrosine_kinase_receptor_type_1
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gptkbp:associatedWith
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gptkb:cancer
congenital insensitivity to pain with anhidrosis (CIPA)
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gptkbp:biologicalProcess
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axon growth
neuronal differentiation
neuronal survival
protein tyrosine kinase activity
transmembrane receptor activity
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gptkbp:encodedBy
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gptkb:NTRK1_gene
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gptkbp:function
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gptkb:receptor_tyrosine_kinase
mediates effects of nerve growth factor (NGF)
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https://www.w3.org/2000/01/rdf-schema#label
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NTRK1 protein
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gptkbp:interactsWith
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gptkb:SHC1
gptkb:PI3K
gptkb:PLCĪ³1
gptkb:GRB2
gptkb:SOS1
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gptkbp:ligand
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gptkb:nerve_growth_factor_(NGF)
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gptkbp:locatedOnChromosome
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1q23.1
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gptkbp:location
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gptkb:cell_membrane
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gptkbp:mutationAssociatedWith
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can be oncogenic in fusion proteins
can lead to neurodevelopmental disorders
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gptkbp:pathway
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gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
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gptkbp:postTranslationalModification
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phosphorylation
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gptkbp:species
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gptkb:Homo_sapiens
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gptkbp:structure
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transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
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gptkbp:UniProtID
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gptkb:P04629
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gptkbp:bfsParent
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gptkb:TRK1
gptkb:TrkA_protein
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gptkbp:bfsLayer
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8
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