Neurotrophic tyrosine kinase receptor type 1

URI: https://gptkb.org/entity/Neurotrophic_tyrosine_kinase_receptor_type_1
GPTKB entity
Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alsoKnownAs gptkb:TrkA
gptkbp:alternativeSplicing multiple isoforms
gptkbp:discoveredBy L.M. Reichardt
gptkbp:Entrez_Gene_ID ENSG00000198400
gptkbp:expressedIn gptkb:nervous_system
gptkbp:firstDescribed 1986
gptkbp:formsHeterodimerWith gptkb:p75NTR
gptkbp:function tyrosine kinase activity
high affinity nerve growth factor receptor
gptkbp:gene gptkb:NTRK1
gptkbp:HGNC_ID 8031
https://www.w3.org/2000/01/rdf-schema#label Neurotrophic tyrosine kinase receptor type 1
gptkbp:involves neuronal differentiation
neuronal survival
gptkbp:ligand gptkb:nerve_growth_factor_(NGF)
gptkbp:locatedOnChromosome 1q23.1
gptkbp:location gptkb:plasma_membrane
gptkbp:molecularWeight ~140 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
gptkbp:OMIM 191315
gptkbp:PDB gptkb:1WWW
gptkbp:phosphorylates tyrosine residues
gptkbp:proteinFamily gptkb:neurotrophic_tyrosine_kinase_receptor_family
gptkbp:targetOfDrug gptkb:entrectinib
gptkb:larotrectinib
gptkbp:UniProtID gptkb:P04629
gptkbp:bfsParent gptkb:TrkA_protein
gptkbp:bfsLayer 8