nerve growth factor (NGF)

URI: https://gptkb.org/entity/nerve_growth_factor_(NGF)
GPTKB entity
Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:protein
neurotrophin
gptkbp:alternativeName gptkb:NGF
gptkb:beta-NGF
gptkbp:biosynthesized_from produced by target tissues of neurons
gptkbp:CASNumber 9061-61-4
gptkbp:category growth factor
signaling molecule
peptide
gptkbp:discoveredBy gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
gptkbp:discoveredIn 1950s
gptkbp:encodedBy NGF gene
gptkbp:function promotes growth and survival of neurons
regulates differentiation of neurons
gptkbp:gene gptkb:NGF
gptkbp:GO GO:0005169
https://www.w3.org/2000/01/rdf-schema#label nerve growth factor (NGF)
gptkbp:locatedOnChromosome gptkb:1p13.1
gptkbp:medicalUse investigated for peripheral neuropathy
investigated for neurodegenerative diseases
gptkbp:MeSH_ID D009422
gptkbp:molecularWeight ~26 kDa
gptkbp:mutationAssociatedWith can cause hereditary sensory and autonomic neuropathy type V
gptkbp:NobelPrizeYear gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
1986
Physiology or Medicine
gptkbp:OMIM 162030
gptkbp:orthologIn gptkb:neurotrophin-3_(NT-3)
gptkb:brain-derived_neurotrophic_factor_(BDNF)
gptkb:neurotrophin-4_(NT-4)
gptkbp:PDB gptkb:1BET
gptkbp:recipient gptkb:TrkA
gptkb:p75NTR
gptkbp:relatedTo gptkb:Alzheimer's_disease
central nervous system
pain modulation
peripheral nervous system
gptkbp:role essential for sympathetic and sensory neuron development
gptkbp:species gptkb:human
gptkb:mouse
right
gptkbp:structure homodimer
gptkbp:UniProtID gptkb:P01138
gptkbp:bfsParent gptkb:CD271
gptkb:NTF3
gptkb:Ngfr
gptkb:Ntrk1
gptkb:TRK_A
gptkb:TrkA_(mouse)
gptkb:neurotrophic_receptor_tyrosine_kinase_1
gptkb:neurotrophic_tyrosine_kinase_receptor_type_1
gptkb:trk-A
gptkbp:bfsLayer 8