|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:alternativeName
|
gptkb:NTRK1_protein
gptkb:Neurotrophic_tyrosine_kinase_receptor_type_1
|
|
gptkbp:binds
|
gptkb:nerve_growth_factor
|
|
gptkbp:discoveredBy
|
gptkb:Louis_Reichardt
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:NTRK1_gene
|
|
gptkbp:expressedIn
|
gptkb:nervous_system
sensory neurons
sympathetic neurons
|
|
gptkbp:formsComplexWith
|
gptkb:NGF
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TrkA protein
|
|
gptkbp:involvedIn
|
gptkb:neurotrophin_signaling_pathway
neuronal differentiation
neuronal survival
|
|
gptkbp:locatedOnChromosome
|
1q23.1
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:Trk_receptor_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
|
|
gptkbp:OMIM
|
191315
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1WWW
4AOJ
5KML
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
cell survival
neurite outgrowth
apoptosis inhibition
|
|
gptkbp:relatedTo
|
gptkb:TrkB_protein
gptkb:TrkC_protein
|
|
gptkbp:target
|
gptkb:entrectinib
gptkb:larotrectinib
tropomyosin receptor kinase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P04629
|
|
gptkbp:bfsParent
|
gptkb:NTRK1
gptkb:NTRK1_gene
|
|
gptkbp:bfsLayer
|
7
|