|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MTC
gptkb:TRK1
gptkb:TRKA
|
|
gptkbp:alternativeName
|
gptkb:TRK
gptkb:MTC
gptkb:TRKA
gptkb:p140-TrkA
|
|
gptkbp:associatedWith
|
gptkb:papillary_thyroid_carcinoma
gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
gptkb:medullary_thyroid_carcinoma
|
|
gptkbp:biologicalProcess
|
gptkb:neurotrophin_signaling_pathway
cell differentiation
nervous system development
apoptosis regulation
receptor activity
protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Mariano_Barbacid
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
gptkb:TrkA_protein
|
|
gptkbp:Entrez_Gene_ID
|
4914
ENSG00000198400
|
|
gptkbp:expressedIn
|
gptkb:nervous_system
sympathetic neurons
|
|
gptkbp:fullName
|
gptkb:neurotrophic_receptor_tyrosine_kinase_1
|
|
gptkbp:function
|
encodes a receptor tyrosine kinase for nerve growth factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:8031
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTRK1 gene
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q23.1
|
|
gptkbp:mutationAssociatedWith
|
cancer predisposition
loss of pain sensation
|
|
gptkbp:OMIM
|
191315
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ntrk1
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:product
|
gptkb:TrkA_receptor
|
|
gptkbp:targetOfDrug
|
gptkb:entrectinib
gptkb:larotrectinib
|
|
gptkbp:UniProtID
|
gptkb:P04629
|
|
gptkbp:bfsParent
|
gptkb:TrkA
|
|
gptkbp:bfsLayer
|
6
|