|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:hepatocyte_growth_factor_receptor
HGFR
|
|
gptkbp:discoveredBy
|
gptkb:George_F._Vande_Woude
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:domain
|
intracellular tyrosine kinase domain
extracellular Sema domain
|
|
gptkbp:encodedBy
|
gptkb:MET_gene
|
|
gptkbp:formsComplexWith
|
gptkb:AKT1
gptkb:ERK1/2
gptkb:GAB1
gptkb:MAPK
gptkb:PLCγ
gptkb:SHC1
gptkb:PI3K
gptkb:RAS
gptkb:FAK
gptkb:SRC
gptkb:p120-catenin
gptkb:GRB2
gptkb:SOS1
gptkb:β-catenin
gptkb:PAX
gptkb:CRK
gptkb:STAT3
DOCK1
VAV2
c-CBL
|
|
gptkbp:function
|
cell survival
morphogenesis
cell growth
cell motility
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MET receptor
|
|
gptkbp:involvedIn
|
signal transduction
tissue regeneration
oncogenesis
|
|
gptkbp:ligand
|
hepatocyte growth factor
|
|
gptkbp:locatedOnChromosome
|
7q31
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
hepatocellular carcinoma
gastric cancer
papillary renal cell carcinoma
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:regulates
|
epithelial-mesenchymal transition
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
single-pass transmembrane protein
|
|
gptkbp:target
|
targeted cancer therapies
tyrosine kinase inhibitors
|
|
gptkbp:UniProtID
|
P08581
|
|
gptkbp:bfsParent
|
gptkb:Tabrecta
|
|
gptkbp:bfsLayer
|
6
|