|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:c-Met
gptkb:hepatocyte_growth_factor_receptor
HGFR
|
|
gptkbp:associatedWith
|
gptkb:cancer
hepatocellular carcinoma
gastric cancer
papillary renal cell carcinoma
|
|
gptkbp:discoveredBy
|
gptkb:George_F._Vande_Woude
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodes
|
gptkb:hepatocyte_growth_factor_receptor
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105976
4233
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
liver
epithelial cells
|
|
gptkbp:function
|
cell survival
morphogenesis
cell growth
cell motility
|
|
gptkbp:HGNC_ID
|
7029
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MET gene
|
|
gptkbp:interactsWith
|
gptkb:GAB1
gptkb:PIK3R1
gptkb:PTPN11
gptkb:SHC1
gptkb:SRC
gptkb:PLCĪ³1
gptkb:GRB2
gptkb:SOS1
gptkb:STAT3
gptkb:c-Cbl
|
|
gptkbp:involvedIn
|
angiogenesis
metastasis
tumorigenesis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q31
|
|
gptkbp:mutationAssociatedWith
|
point mutation
amplification
gain-of-function
exon 14 skipping
|
|
gptkbp:OMIM
|
164860
|
|
gptkbp:orthologInMouse
|
gptkb:Met
|
|
gptkbp:pathway
|
HGF/MET signaling pathway
|
|
gptkbp:phosphorylates
|
Y1234
Y1235
Y1349
Y1356
|
|
gptkbp:product
|
gptkb:receptor_tyrosine_kinase
gptkb:c-Met
|
|
gptkbp:regulates
|
epithelial-mesenchymal transition
invasive growth
|
|
gptkbp:target
|
gptkb:crizotinib
gptkb:capmatinib
gptkb:savolitinib
gptkb:tepotinib
gptkb:cabozantinib
|
|
gptkbp:UniProtID
|
P08581
|
|
gptkbp:bfsParent
|
gptkb:c-Met
|
|
gptkbp:bfsLayer
|
6
|