Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
EGFR signaling pathway
insulin receptor signaling |
| gptkbp:form |
multiple isoforms exist
|
| gptkbp:function |
acts as an adapter protein
|
| gptkbp:has_binding_site |
SH2 domain
PTB domain |
| gptkbp:has_role |
tumorigenesis
metastasis |
| https://www.w3.org/2000/01/rdf-schema#label |
GAB1
|
| gptkbp:interacts_with |
gptkb:SHC1
gptkb:GRB2 PI3 K |
| gptkbp:involved_in |
cell proliferation
cell survival |
| gptkbp:is_expressed_in |
various tissues
|
| gptkbp:is_involved_in |
gptkb:diabetes
gptkb:neurodegenerative_diseases apoptosis regulation cell cycle regulation cell differentiation cellular homeostasis developmental processes immune response autoimmune diseases chronic diseases inflammation metabolic syndrome obesity wound healing stress response fibrosis infectious diseases neuronal signaling tissue regeneration cancer progression angiogenesis aging process cell adhesion cell migration cardiovascular function signal amplification cellular repair mechanisms metabolic regulation endothelial cell function neurodevelopment hormonal signaling extracellular matrix interaction growth factor signaling cytokine signaling cellular response to stimuli receptor tyrosine kinase signaling |
| gptkbp:is_part_of |
signal transduction pathways
|
| gptkbp:is_regulated_by |
phosphorylation
|
| gptkbp:is_studied_in |
gptkb:Oncology
|
| gptkbp:located_in |
cytoplasm
plasma membrane |
| gptkbp:promoter |
GAB1 gene
|
| gptkbp:targets |
cancer therapies
|
| gptkbp:weight |
approximately 100 k Da
|
| gptkbp:bfsParent |
gptkb:PIK3_CA
|
| gptkbp:bfsLayer |
6
|