|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PTK2
gptkb:Protein_Tyrosine_Kinase_2
FADK
pp125FAK
|
|
gptkbp:discoveredBy
|
gptkb:Thomas_Parsons
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
gptkb:FAT_domain
kinase domain
FERM domain
proline-rich regions
|
|
gptkbp:enzymeClassification
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Focal_Adhesion_Kinase
|
|
gptkbp:function
|
cell proliferation
signal transduction
cell migration
cell adhesion regulation
|
|
gptkbp:gene
|
gptkb:PTK2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FAK
|
|
gptkbp:interactsWith
|
gptkb:Src
gptkb:PI3K
gptkb:integrins
gptkb:Grb2
gptkb:paxillin
gptkb:talin
p130Cas
|
|
gptkbp:locale
|
focal adhesions
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24.3
|
|
gptkbp:molecularWeight
|
125 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
2J0J
|
|
gptkbp:phosphorylates
|
Y397
Y576
Y577
Y861
Y925
|
|
gptkbp:regulates
|
autophosphorylation
growth factor signaling
integrin signaling
|
|
gptkbp:role
|
gptkb:cancer
inflammation
metastasis
fibrosis
|
|
gptkbp:target
|
gptkb:defactinib
small molecule inhibitors
VS-4718
|
|
gptkbp:UniProtID
|
Q05397
|
|
gptkbp:bfsParent
|
gptkb:PTK2
gptkb:Royal_Danish_Defence_College
|
|
gptkbp:bfsLayer
|
6
|