Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:MAP_kinase_kinase_(MEK)
|
| gptkbp:alternativeName |
gptkb:MAPK
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:encodedBy |
MAPK genes
|
| gptkbp:enzymeClassification |
gptkb:EC_2.7.11.24
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:fullName |
gptkb:Mitogen-activated_protein_kinase
|
| gptkbp:function |
phosphorylates target proteins
|
| gptkbp:inhibitedBy |
MAPK inhibitors
|
| gptkbp:involvedIn |
signal transduction
cellular response to extracellular stimuli |
| gptkbp:involves |
gptkb:cancer
neurodegenerative diseases developmental disorders inflammatory diseases |
| gptkbp:partOf |
gptkb:MAPK/ERK_pathway
gptkb:MAPK/JNK_pathway gptkb:MAPK/p38_pathway |
| gptkbp:phosphorylates |
tyrosine residues
serine residues threonine residues |
| gptkbp:regulates |
apoptosis
cell differentiation cell survival gene expression cell division |
| gptkbp:subspecies |
gptkb:JNK
gptkb:p38_MAPK gptkb:ERK |
| gptkbp:bfsParent |
gptkb:MAPK/ERK_pathway
|
| gptkbp:bfsLayer |
5
|