Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:Mitogen-activated_protein_kinase_kinase
|
| gptkbp:activatedBy |
gptkb:MAP_kinase_kinase_kinase_(MAP3K)
|
| gptkbp:alternativeName |
gptkb:MEK
|
| gptkbp:catalyzes |
phosphorylation of MAPK
|
| gptkbp:enzymeCommissionNumber |
2.7.12.2
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:fullName |
gptkb:Mitogen-activated_protein_kinase_kinase
|
| gptkbp:function |
phosphorylates MAP kinases
|
| gptkbp:hasIsoform |
gptkb:MKK3
gptkb:MKK4 gptkb:MKK6 gptkb:MKK7 gptkb:MKK5 gptkb:MKK1 gptkb:MKK2 |
| https://www.w3.org/2000/01/rdf-schema#label |
MKK
|
| gptkbp:involvedIn |
gptkb:MAPK_signaling_pathway
|
| gptkbp:proteinFamily |
gptkb:MAP2K
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation stress response |
| gptkbp:relatedTo |
gptkb:ERK_pathway
gptkb:JNK_pathway gptkb:p38_MAPK_pathway |
| gptkbp:target |
pharmaceutical inhibitors (e.g., MEK inhibitors)
|
| gptkbp:bfsParent |
gptkb:Main-Kinzig-Kreis
gptkb:Schlüchtern,_Germany gptkb:Maintal |
| gptkbp:bfsLayer |
6
|