Mitogen-Activated Protein Kinase pathway
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
cytokines
growth factors cellular stress |
| gptkbp:alsoKnownAs |
gptkb:MAPK_pathway
|
| gptkbp:component |
gptkb:ERK5_pathway
gptkb:ERK_pathway gptkb:JNK_pathway gptkb:p38_MAPK_pathway |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases inflammatory diseases |
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
eukaryotic cells
|
| https://www.w3.org/2000/01/rdf-schema#label |
Mitogen-Activated Protein Kinase pathway
|
| gptkbp:involves |
gptkb:MAPK
gptkb:Ras_protein gptkb:MAP2K gptkb:MAP3K gptkb:MAP_kinase_kinase gptkb:MAP_kinase_kinase_kinase MAP kinase transcription factors phosphatases adaptor proteins ERK protein JNK protein MEK protein Raf protein p38 protein scaffold proteins |
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation cell survival development gene expression metabolism cell migration immune response cell cycle stress response |
| gptkbp:signalTransductionType |
phosphorylation cascade
|
| gptkbp:studiedIn |
gptkb:yeast
mammals plants |
| gptkbp:target |
cancer therapies
therapeutic drugs |
| gptkbp:bfsParent |
gptkb:MAPK_pathway
|
| gptkbp:bfsLayer |
7
|