Mitogen-Activated Protein Kinase pathway

URI: https://gptkb.org/entity/Mitogen-Activated_Protein_Kinase_pathway
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:biological_pathway
gptkbp:activatedBy cytokines
growth factors
cellular stress
gptkbp:alsoKnownAs gptkb:MAPK_pathway
gptkbp:component gptkb:ERK5_pathway
gptkb:ERK_pathway
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
gptkbp:dysregulationAssociatedWith gptkb:cancer
neurodegenerative diseases
inflammatory diseases
gptkbp:firstDescribed 1990s
gptkbp:foundIn eukaryotic cells
gptkbp:involves gptkb:MAPK
gptkb:MAP_kinase
gptkb:Ras_protein
gptkb:MAP2K
gptkb:MAP3K
gptkb:MAP_kinase_kinase
gptkb:MAP_kinase_kinase_kinase
transcription factors
phosphatases
adaptor proteins
ERK protein
JNK protein
MEK protein
Raf protein
p38 protein
scaffold proteins
gptkbp:regulates gptkb:immune_response
apoptosis
cell differentiation
cell proliferation
cell survival
development
gene expression
metabolism
cell migration
cell cycle
stress response
gptkbp:signalTransductionType phosphorylation cascade
gptkbp:studiedIn gptkb:yeast
mammals
plants
gptkbp:target cancer therapies
therapeutic drugs
gptkbp:bfsParent gptkb:MAPK_pathway
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Mitogen-Activated Protein Kinase pathway