|
gptkbp:instanceOf
|
gptkb:guanine_nucleotide_exchange_factor
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:function
|
gptkb:molecular_switch
|
|
gptkbp:includes
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:inhibitedBy
|
GTPase-activating proteins
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
|
|
gptkbp:involves
|
signal transduction
developmental disorders
oncogenesis
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:member
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:orthologIn
|
gptkb:Drosophila
gptkb:C._elegans
gptkb:yeast
mammals
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
cell growth
cell migration
|
|
gptkbp:requires
|
embryonic development
tissue homeostasis
|
|
gptkbp:signal_transduction_pathway
|
gptkb:MAPK_pathway
gptkb:PI3K_pathway
|
|
gptkbp:structure
|
G domain
switch I region
switch II region
|
|
gptkbp:target
|
farnesyltransferase inhibitors
covalent inhibitors (KRAS G12C)
|
|
gptkbp:bfsParent
|
gptkb:RAS_superfamily
|
|
gptkbp:bfsLayer
|
5
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
Ras GTPases
|