|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK1
gptkb:MAPK1
|
|
gptkbp:amendedBy
|
phosphorylation
dephosphorylation
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:MAPK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5594
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.24
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:family
|
gptkb:MAP_kinase_family
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:MAPK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p44MAPK
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:locatedOnChromosome
|
22q11.22
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:participatedIn
|
cellular response to growth factors
cellular response to stress
|
|
gptkbp:PDB
|
2ZOQ
|
|
gptkbp:phosphorylates
|
transcription factors
Thr202
Tyr204
|
|
gptkbp:RefSeq
|
NP_002736.3
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
gene expression
|
|
gptkbp:relatedTo
|
gptkb:ERK2
gptkb:p42MAPK
|
|
gptkbp:significance
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:structure
|
protein kinase domain
|
|
gptkbp:subfamily
|
gptkb:ERK_subfamily
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:MAPK3
gptkb:MAPK3_gene
|
|
gptkbp:bfsLayer
|
7
|