|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:ERBB3
gptkb:ErbB-3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
drug resistance
|
|
gptkbp:binds
|
neuregulins
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
ERBB3 gene
|
|
gptkbp:Entrez_Gene_ID
|
2065
|
|
gptkbp:expressedIn
|
epithelial tissues
|
|
gptkbp:formsHeterodimerWith
|
gptkb:EGFR
gptkb:HER4
HER2
|
|
gptkbp:function
|
differentiation
survival
cell signaling
proliferation
regulation of cell growth
|
|
gptkbp:hasNo
|
intrinsic kinase activity
|
|
gptkbp:HGNC_ID
|
3431
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HER3
|
|
gptkbp:involves
|
gptkb:cancer
colorectal cancer
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13
|
|
gptkbp:memberOf
|
gptkb:receptor_tyrosine_kinases
gptkb:ErbB_family
|
|
gptkbp:molecularWeight
|
~145 kDa
|
|
gptkbp:OMIM
|
190151
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1M6B
|
|
gptkbp:phosphorylates
|
gptkb:EGFR
HER2
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Cancer
Cell Signaling journals
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
intracellular domain
transmembrane domain
extracellular ligand-binding domain
|
|
gptkbp:target
|
anticancer drugs
monoclonal antibodies
tyrosine kinase inhibitors
|
|
gptkbp:UniProtID
|
P21860
|
|
gptkbp:bfsParent
|
gptkb:ERBB3
gptkb:HER2/neu
gptkb:HER2/neu_receptor
gptkb:HER2_receptor
gptkb:HER1
gptkb:Her2
gptkb:HER2_protein
|
|
gptkbp:bfsLayer
|
7
|