|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
ErbB4
receptor tyrosine-protein kinase erbB-4
|
|
gptkbp:binds
|
gptkb:betacellulin
gptkb:epiregulin
gptkb:heparin-binding_EGF-like_growth_factor
neuregulins
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
|
|
gptkbp:encodedBy
|
ERBB4 gene
|
|
gptkbp:Entrez_Gene_ID
|
2066
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
breast tissue
|
|
gptkbp:formsHeterodimerWith
|
gptkb:EGFR
gptkb:HER3
HER2
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:HGNC_ID
|
3431
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HER4
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell survival
cell growth
cell signaling
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:cardiovascular_disease
schizophrenia
|
|
gptkbp:locatedOn
|
chromosome 2q34
|
|
gptkbp:memberOf
|
gptkb:ErbB_family
|
|
gptkbp:molecularWeight
|
~180 kDa
|
|
gptkbp:OMIM
|
600543
|
|
gptkbp:PDB
|
2AHX
|
|
gptkbp:phosphorylates
|
activates downstream signaling pathways
|
|
gptkbp:regulates
|
alternative splicing
proteolytic cleavage
|
|
gptkbp:structure
|
single-pass transmembrane protein
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
Q15303
|
|
gptkbp:bfsParent
|
gptkb:HER2/neu
gptkb:HER2/neu_receptor
gptkb:HER2_receptor
gptkb:ERBB4
gptkb:HER1
gptkb:Her2
gptkb:HER2_protein
|
|
gptkbp:bfsLayer
|
7
|