|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:cell_division_protein_kinase_2
gptkb:CDKN2
gptkb:p33(CDK2)
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
cell division
DNA replication
protein serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
David Morgan et al.
|
|
gptkbp:encodes
|
gptkb:Cyclin-dependent_kinase_2
|
|
gptkbp:Entrez_Gene_ID
|
1017
ENSG00000123374
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:function
|
regulation of cell cycle
G1/S transition of mitotic cell cycle
|
|
gptkbp:HGNC_ID
|
HGNC:1771
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK2 gene
|
|
gptkbp:inhibitedBy
|
gptkb:purvalanol_A
gptkb:roscovitine
|
|
gptkbp:interactsWith
|
gptkb:CDKN1A_(p21)
gptkb:CDKN1B_(p27)
gptkb:Cyclin_A
gptkb:Cyclin_E
|
|
gptkbp:length
|
298 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.2
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:mutationAssociatedWith
|
cell cycle arrest
impaired DNA replication
|
|
gptkbp:OMIM
|
116946
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk2
|
|
gptkbp:pathway
|
DNA damage response
p53 signaling pathway
cell cycle pathway
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:proteinFamily
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:regulates
|
activated by cyclin binding
inhibited by CDK inhibitors
|
|
gptkbp:requires
|
cell proliferation
meiotic cell cycle
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
P24941
|
|
gptkbp:bfsParent
|
gptkb:CDK2
|
|
gptkbp:bfsLayer
|
7
|