|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:CDC25_phosphatases
gptkb:Cyclin_B
|
|
gptkbp:alternativeName
|
gptkb:cell_division_control_protein_2_homolog
gptkb:p34_protein_kinase
gptkb:CDC2
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Paul_Nurse
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:EC_number
|
2.7.11.22
|
|
gptkbp:Entrez_Gene_ID
|
983
|
|
gptkbp:expressedIn
|
all dividing cells
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_1
|
|
gptkbp:function
|
cell cycle regulation
mitosis
G2/M transition
|
|
gptkbp:gene
|
gptkb:CDK1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:1722
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK1
|
|
gptkbp:inhibitedBy
|
gptkb:p21
gptkb:p27
|
|
gptkbp:interactsWith
|
gptkb:CDC25C
gptkb:Cyclin_B1
gptkb:Cyclin_A
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q21.2
|
|
gptkbp:OMIM
|
116940
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:4Y72
|
|
gptkbp:phosphorylates
|
gptkb:histone_H1
|
|
gptkbp:regulates
|
DNA replication
cytokinesis
mitotic exit
chromosome condensation
mitotic entry
nuclear envelope breakdown
spindle assembly
|
|
gptkbp:significance
|
oncology
cell cycle disorders
|
|
gptkbp:target
|
anticancer drugs
CDK inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P06493
|
|
gptkbp:bfsParent
|
gptkb:cdc2
|
|
gptkbp:bfsLayer
|
5
|