Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
target proteins
|
| gptkbp:code |
CDC2 gene
|
| gptkbp:function |
regulates cell cycle progression
|
| gptkbp:has_role |
DNA damage response
|
| https://www.w3.org/2000/01/rdf-schema#label |
CDK1
|
| gptkbp:initiated_by |
gptkb:cyclin_B
dephosphorylation p21 p27 DNA damage response proteins mitotic cyclins |
| gptkbp:interacts_with |
gptkb:cyclin_B
|
| gptkbp:involved_in |
mitosis
|
| gptkbp:is_associated_with |
cellular senescence
|
| gptkbp:is_essential_for |
cell division
|
| gptkbp:is_expressed_in |
gptkb:embryonic_development
various tissues cancer cells proliferating cells |
| gptkbp:is_involved_in |
gptkb:neurodegenerative_diseases
meiosis apoptosis cellular homeostasis cellular metabolism cellular stress response chromosome segregation immune response cellular response to stress tumorigenesis cellular differentiation tissue regeneration cellular signaling pathways stem cell maintenance cellular repair mechanisms cellular adaptation mechanisms cellular aging processes cellular repair processes cancer metastasis cellular communication. |
| gptkbp:is_linked_to |
aging
metabolic disorders chronic diseases cellular proliferation cancer progression developmental disorders therapeutic resistance |
| gptkbp:is_part_of |
cell cycle regulation
signal transduction pathways cellular signaling cascades cancer treatment strategies cellular signaling networks cellular growth regulation cellular response to stimuli mitotic spindle assembly cell cycle checkpoint control |
| gptkbp:is_regulated_by |
phosphorylation
cyclin-dependent kinase inhibitors |
| gptkbp:is_targeted_at |
small molecule inhibitors
anticancer drugs |
| gptkbp:location |
gptkb:Atom
|
| gptkbp:orthologs |
many species
|
| gptkbp:weight |
approximately 34 k Da
|
| gptkbp:bfsParent |
gptkb:Cyclin-dependent_kinase
|
| gptkbp:bfsLayer |
6
|