|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:COPEB
gptkb:GBF
Zf9
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
colorectal cancer
prostate cancer
hepatocellular carcinoma
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
gptkb:Kruppel-like_factor_6_protein
|
|
gptkbp:Entrez_Gene_ID
|
1316
ENSG00000167772
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
gptkb:prostate
liver
|
|
gptkbp:fullName
|
gptkb:Kruppel-like_factor_6
|
|
gptkbp:function
|
transcription factor
tumor suppression
regulation of cell growth
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:6346
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KLF6
|
|
gptkbp:interactsWith
|
gptkb:SP1
gptkb:Cyclin_D1
gptkb:p53
|
|
gptkbp:length
|
283 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
|
|
gptkbp:molecularWeight
|
30 kDa
|
|
gptkbp:mutationAssociatedWith
|
loss of function associated with cancer
|
|
gptkbp:OMIM
|
602053
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Klf6
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:Kruppel-like_factors
zinc finger domain
|
|
gptkbp:regulates
|
gptkb:CDKN1A_(p21)
gptkb:E-cadherin
apoptosis
differentiation
cell cycle
TGF-beta pathway genes
binds GC-rich elements
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
Q99612
|
|
gptkbp:bfsParent
|
gptkb:Sp/KLF_transcription_factor_family
gptkb:EWSR1
gptkb:GKLF
gptkb:Kruppel-like_factors
|
|
gptkbp:bfsLayer
|
7
|