|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:hypoxia
DNA damage
oncogenic stress
|
|
gptkbp:alsoKnownAs
|
gptkb:tumor_protein_p53
|
|
gptkbp:biologicalProcess
|
transcription factor
protein-protein interaction
DNA binding
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodes
|
gptkb:p53_protein
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:hasTranscriptVariant
|
gptkb:NM_000546
NM_001126112
NM_001126113
NM_001276760
NM_001276761
|
|
gptkbp:HGNC_ID
|
11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tp53
|
|
gptkbp:inhibitedBy
|
gptkb:MDM2
gptkb:MDM4
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
17p13.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Li-Fraumeni_syndrome
nonsense
deletion
insertion
missense
various cancers
frameshift
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Trp53
gptkb:Tp53
|
|
gptkbp:orthologInZebrafish
|
tp53
|
|
gptkbp:product
|
gptkb:p53
tetramer
|
|
gptkbp:proteinFamily
|
regulatory domain
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:regulates
|
gptkb:CDKN1A_(p21)
gptkb:BAX
gptkb:GADD45
gptkb:NOXA
gptkb:PUMA
gptkb:MDM2
apoptosis
cell differentiation
DNA repair
metabolism
angiogenesis
immune response
cell cycle
senescence
autophagy
cellular stress response
genomic stability
stem cell self-renewal
|
|
gptkbp:significance
|
target for cancer therapy
biomarker for cancer prognosis
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:TP53
|
|
gptkbp:bfsLayer
|
6
|