|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
AML2
CBFA3
PEBP2-alphaC
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
gastric cancer
tumor suppressor activity
|
|
gptkbp:chromosomeArm
|
gptkb:1p36
|
|
gptkbp:encodes
|
Runt-related transcription factor 3
|
|
gptkbp:Entrez_Gene_ID
|
864
ENSG00000020633
|
|
gptkbp:expressedIn
|
neurons
hematopoietic cells
gastric epithelium
|
|
gptkbp:firstDescribed
|
1999
|
|
gptkbp:function
|
transcription factor
regulation of gene expression
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:HGNC_ID
|
10473
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RUNX3
|
|
gptkbp:interactsWith
|
gptkb:SMAD_proteins
gptkb:p300
BRD2
CBF-beta
|
|
gptkbp:involvedIn
|
gptkb:TGF-beta_signaling_pathway
immune response
neuronal development
hematopoiesis
|
|
gptkbp:length
|
415 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
|
|
gptkbp:memberOf
|
gptkb:RUNX_family
|
|
gptkbp:methylationStatus
|
hypermethylated in some cancers
|
|
gptkbp:molecularWeight
|
42 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
|
|
gptkbp:orthologInMouse
|
Runx3
|
|
gptkbp:proteinFamily
|
Runt domain
|
|
gptkbp:regulates
|
gptkb:CDKN1A_(p21)
gptkb:IL-2
gptkb:IFN-gamma
apoptosis
cell differentiation
cell proliferation
BIM
T-bet
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
Q13761
|
|
gptkbp:bfsParent
|
gptkb:SMAD4_gene
|
|
gptkbp:bfsLayer
|
7
|