|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PI3K_pathway
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:Protein_kinase_B
gptkb:PKB
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:category
|
gptkb:enzyme
tumor suppressor
|
|
gptkbp:discoveredBy
|
gptkb:Philip_Cohen
gptkb:Dario_Alessi
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of cell survival
regulation of cell growth
regulation of glucose metabolism
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Akt
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
phosphatases
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:orthologIn
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
|
gptkbp:orthologInMouse
|
gptkb:Akt1
gptkb:Akt2
gptkb:Akt3
|
|
gptkbp:pathway
|
gptkb:PI3K/AKT/mTOR_pathway
|
|
gptkbp:phosphorylates
|
Ser473
Thr308
|
|
gptkbp:proteinFamily
|
gptkb:AGC_kinase_family
|
|
gptkbp:structure
|
gptkb:PH_domain
regulatory domain
serine/threonine kinase domain
|
|
gptkbp:substrate
|
gptkb:FOXO
gptkb:GSK-3
gptkb:TSC2
gptkb:BAD
gptkb:MDM2
gptkb:mTOR
gptkb:p27_Kip1
|
|
gptkbp:UniProtID
|
gptkb:P31749
P31751
Q9Y243
|
|
gptkbp:bfsParent
|
gptkb:BAD_protein
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|