|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PKB_beta
gptkb:Protein_kinase_B_beta
gptkb:RAC-beta_serine/threonine-protein_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes_mellitus
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
gptkb:PH_domain
kinase domain
regulatory domain
|
|
gptkbp:encodedBy
|
gptkb:AKT2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105221
208
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
gptkbp:hasIsoform
|
gptkb:AKT2-001
gptkb:AKT2-002
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:391
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT2
|
|
gptkbp:involvedIn
|
cell survival
glucose metabolism
insulin signaling pathway
|
|
gptkbp:KEGGID
|
gptkb:hsa:208
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
19q13.2
|
|
gptkbp:memberOf
|
gptkb:AKT_family
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hypoglycemia
severe insulin resistance
|
|
gptkbp:OMIM
|
164731
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Akt2
|
|
gptkbp:PDB
|
gptkb:1O6K
|
|
gptkbp:phosphorylates
|
gptkb:FOXO1
gptkb:GSK3B
gptkb:BAD
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:ReactomeID
|
gptkb:R-HSA-1257604
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
glycogen synthesis
glucose transporter type 4 (GLUT4) translocation
|
|
gptkbp:UniProtID
|
P31751
|
|
gptkbp:bfsParent
|
gptkb:AKT_(protein_kinase_B)
gptkb:AKT
gptkb:AKT_pathway
gptkb:PDK1
gptkb:KEGG:_hsa04014
|
|
gptkbp:bfsLayer
|
6
|